Statistical Significance of Precisely Repeated Intracellular Synaptic Patterns

Statistical Significance of Precisely Repeated Intracellular Synaptic Patterns

Can neuronal networks produce patterns of activity with millisecond accuracy? It may seem unlikely, considering the probabilistic nature of synaptic transmission. However, some theories of brain function predict that such precision is feasible and can emerge from the non-linearity of the action potential generation in circuits of connected neurons. Several studies have presented evidence for an...

Statistical Significance of Patterns in Biosequences

Several algorithms for pattern discovery in sequences have recently emerged, such as Pratt, Teiresias, Splash, and Meme. These are proving useful in biological sequences analysis, as the presence of statistically or biologically significant patterns may indicate subtle relationships that complement those discovered through local sequence alignment tools such as BLAST or FASTA [1, 10]. Statistic...

Statistical and Practical Significance of Articles at Sports Biomechanics Conferences

Background. The importance of using statistical approaches has increased and became necessary for researchers and specialists in sports biomechanics because they need more objective and accurate methods to increase knowledge. Objectives. Evaluate the reality of using practical significance in the articles published in scientific conferences in the biomechanical sport. Methods. One hundred twe...

Motor control by precisely timed spike patterns.

A fundamental problem in neuroscience is understanding how sequences of action potentials ("spikes") encode information about sensory signals and motor outputs. Although traditional theories assume that this information is conveyed by the total number of spikes fired within a specified time interval (spike rate), recent studies have shown that additional information is carried by the millisecon...

Statistical significance and clinical significance.